# NIH grant: Night shift work among pregnant healthcare workers (1K23HL186119-01) — retained record

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[original source ↗](https://reporter.nih.gov/project-details/1K23HL186119-01)

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NIH grant 1K23HL186119-01: Night shift work among pregnant healthcare workers
Institute: {'code': 'HL', 'abbreviation': 'NHLBI', 'name': 'National Heart Lung and Blood Institute', 'admin_org_id': '12500068', 'admin_funding_url': ''}. PI: Isha  Agarwal. Award: $187235.
Start: 2026-08-15T00:00:00.
PROJECT SUMMARY/ABSTRACT
Isha Agarwal, MD ScD is an Assistant Professor of Emergency Medicine at MaineHealth, with a dual
appointment at Tufts University School of Medicine (MaineHealth’s academic affiliate). She seeks a Mentored
Patient-Oriented Research Career Development Award to develop fundamental scientific knowledge and skills
in key areas that will prepare her to launch an independent research career focused on understanding the role
of night shift work, and more generally sleep, on women’s perinatal and long-term cardiometabolic health. Dr.
Agarwal’s proposed five-year training, career development, and research plan builds upon her outstanding
academic background, including doctoral thesis work in cardiovascular epidemiology, more recent work on the
cardiometabolic impacts of night shift work and other occupational exposures, and clinical experience as an
emergency physician who works night shifts. Dr. Agarwal has identified key focus areas in which she requires
additional in-depth training including perinatal/reproductive epidemiology, sleep, and circadian disruption,
qualitative research, and translating scientific evidence to practical change in occupational health. Her training
goals are highly-integrated with her proposed research plan, which aims to: 1) identify key social-economic
predictors of night shift work during pregnancy, 2) determine the impact of night shift work pre-pregnancy and
during pregnancy on cardiometabolic adverse pregnancy outcomes independent of social-economic factors,
and 3) characterize the barriers and facilitators of requesting and granting night shift work accommodations
among pregnant night shift workers and their employers. Dr. Agarwal proposes a mixed quantitative and
qualitative approach, leveraging detailed data on shift work and pregnancy outcomes from a large,
occupational cohort of US nurses (Nurses’ Health Study II), and supplementing this with a new qualitative
evaluation of pregnant healthcare workers and their employers at three US hospitals. Dr. Agarwal’s mentors,
Dr. Abby Fleisch (perinatal epidemiology), Dr. Deirdre Tobias (cardiometabolic disease epidemiology), and Dr.
Charles Reynolds (sleep and circadian disruption), have related and complementary expertise relevant to Dr.
Agarwal’s training goals and research aims, and prior experience mentoring K-awardees. Dr. Agarwal’s unique
dual affiliation with both MaineHealth and Tufts will enable her to benefit from the exceptional scientific
environment and robust institutional support provided by both institutions, and will facilitate her interactions with
her proposed team of mentors and advisors in Maine and Boston. Dr. Agarwal will emerge from the K23
period with critical knowledge and skills to launch an independent research career focused on understanding
the role of night shift work, and more generally sleep, on women’s perinatal and long-term cardiometabolic
health.
```



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