# NIH grant: A Smart Remote Monitoring System for Cardiometabolic Management in Patients with Alzheimer's and Related Dementia (1R43AG099700-01) — retained record

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[original source ↗](https://reporter.nih.gov/project-details/1R43AG099700-01)

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NIH grant 1R43AG099700-01: A Smart Remote Monitoring System for Cardiometabolic Management in Patients with Alzheimer's and Related Dementia
Institute: {'code': 'AG', 'abbreviation': 'NIA', 'name': 'National Institute on Aging', 'admin_org_id': '12500002', 'admin_funding_url': ''}. PI: Kaustubh  Kale. Award: $500000.
Start: 2026-09-18T00:00:00.
PROJECT SUMMARY/ABSTRACT
Heart failure (HF) remains the leading cause of hospitalization in adults over 65, with more than 1 million
admissions annually in the U.S. and direct costs exceeding $30 billion. Among individuals with Alzheimer’s
Disease and Related Dementias (AD/ADRD)—projected to affect 13 million Americans by 2050—over 60% have
coexisting cardiovascular disease, and up to 40% of HF patients experience cognitive impairment. These
individuals face up to 50% higher 6-month readmission rates, largely due to reduced ability to perform self-
monitoring, medication adherence, and symptom recognition. While a few attempts have been made to use
remote monitoring and digital health tools to support care coordination, current solutions are fragmented. They
typically address only one component of care (e.g., weight tracking or blood pressure) and lack integration across
patient, caregiver, and clinician workflows. There is no existing system that provides a unified platform to support
self-care in cognitively impaired individuals, assist caregivers in clinical decision-making, and facilitate real-time
information sharing across multidisciplinary care teams. This project introduces a novel, integrated home-based
cardiac monitoring system designed specifically for the AD/ADRD population with comorbid HF- HeartMind™:
Bridging Heart Health and Cognitive Care at Home. The system consists of 1) A lightweight, FDA-registered
wearable biosensor that captures intracardiac pressure estimates, heart rate, respiratory rate, and
posture/activity data. 2) An AI-driven care coordination platform that analyzes trends and generates early-
warning alerts for caregivers and clinicians when decompensation risk rises. 3) A caregiver-focused mobile
application with simplified, dementia-friendly interfaces, offering real-time guidance, visual symptom tracking,
educational content, and communication tools. 4) Seamless data integration with electronic health records
(EHRs) and telehealth systems, enabling clinicians to receive structured alerts, access longitudinal trends, and
issue medication changes remotely. Using HEMOTAG – our commercially available technology from Aventusoft
- over a 30-day daily monitoring period, demonstrated ~90% daily adherence, 92% accuracy, and caregiver-
reported ease-of-use. Early decompensations were successfully managed remotely based on device alerts,
avoiding hospitalizations. Caregivers and clinicians reported improved confidence in managing care and greater
perceived control. To validate feasibility during the Phase I, a 15-patient usability pilot will be conducted involving
individuals with mild to moderate AD/ADRD and NYHA Class II–III HF. This project establishes a comprehensive
cardiac care coordination platform that fills the current void in integrated chronic disease management for
cognitively impaired populations. By enabling shared decision-making, proactive monitoring, and remote clinical
intervention, it aims to reduce preventable hospitalizations, lower healthcare costs, and enhance quality of life
for both patients and their caregivers. Following a successful Phase I, a larger clinical trial is planned to assess
long-term outcomes, health system integration, and caregiver impact.
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