# NIH grant: Development of Adipose Derived Stems Cells System for HCMV latency (1R03AI199793-01) — retained record

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source: [us-gov-api](https://highsignal.app/data/us-gov-api) (us-gov-api:nih-reporter)  published 2026-06-24 00:00 ingested 2026-06-29 10:35

[original source ↗](https://reporter.nih.gov/project-details/1R03AI199793-01)

## retained text



```
NIH grant 1R03AI199793-01: Development of Adipose Derived Stems Cells System for HCMV latency
Institute: {'code': 'AI', 'abbreviation': 'NIAID', 'name': 'National Institute of Allergy and Infectious Diseases', 'admin_org_id': '12500003', 'admin_funding_url': ''}. PI: TIMOTHY E SPARER. Award: $148519.
Start: 2026-06-24T00:00:00.
Project Summary/Abstract
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes lifelong
latency and poses a serious threat to immunocompromised individuals and developing
fetuses. A major barrier to developing effective antiviral therapies is our limited
understanding of the mechanisms governing HCMV latency, due in part to challenges in
modeling this process in physiologically relevant human cells. This R03 project proposes
to establish adipose-derived stem cells (ADSCs) as a novel, scalable, and biologically
relevant in vitro model of HCMV latency. We will define the conditions under which ADSCs
support latent infection and compare their transcriptional program to established latency
models using RNA sequencing. This research will advance our understanding of HCMV
latency and provide a critical tool for future studies aimed at developing therapies to
prevent viral reactivation in vulnerable populations.
```



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