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Want to keep track of the largest startup funding deals in 2026 with our curated list of $100 million-plus venture deals to U.S.-based companies? Check out The Crunchbase Megadeals Board. This is a weekly feature that runs down the week’s Top 10 announced funding rounds in the U.S. Check out last week’s biggest funding deal roundup here. This week delivered a bountiful supply of big startup funding rounds, led by two $400 million financings for cybersecurity unicorns Island and Cyera. Rounding out the week were large financings for startups across hot sectors, including foundational AI, drug discovery, neurotech, and even rainmaking. 1. Island, $400M, cybersecurity: Island, a developer of tools for secure enterprise digital operations, raised $400 million in Series F financing. Evolution Equity Partners led the round, which set a $6.4 billion valuation for the Dallas-based company, more than double its 2024 valuation. 2. Cyera, $400M, cybersecurity: Cyera, a provider of enterprise data security tools that govern both humans and AI agents, picked up $400 million in Series G extension funding led by Evolution Equity Partners and backed by Goldman Sachs Growth Equity. The round brings total funding for New York-based Cyera to $2.7 billion, per Crunchbase data. 3. Snorkel AI, $350M, foundational AI: San Francisco-based Snorkel AI, provider of tools for frontier labs and AI teams to develop specialized training data and environments, secured $350 million in Series E funding. Insight Partners and S32 led the round, valuing the 7-year-old company at $3.2 billion, and it now has more than $375 million in annual recurring revenue. 4. Enveda, $311M, biotech: Enveda, an AI-enabled drug discovery startup, closed on $311 million in Series E financing led by Catalio Capital Management and joined by a long list of new and existing investors. The round brings the Boulder, Colorado-based company’s total capital raised since inception to more than $845 million. 5. Precision Neuroscience, $250M, neurotech: New York-based Precision Neuroscience, a startup focused on brain-computer interface technology, secured $250 million in Series D funding with Pershing Square and the Ackman Oxman Institute as lead investors. 6. Hubble Network, $200M, wireless communications: Hubble Network, operator of a satellite network that extends connectivity to Bluetooth devices, pulled in $200 million in Series C funding. Smith Point Capital led the financing, which set a $1.6 billion valuation for the Seattle-based company. 7. Rightway, $155M, pharmacy benefits: New York-based Rightway, a provider of pharmacy benefits and care navigation services, raised $155 million in Series E funding led by Francisco Partners. The startup will use the financing in part to expand its AI capabilities. 8. (tied) Rainmaker, $100M, cloud seeding: El Segundo, California-based Rainmaker, a startup focused on atmospheric research and producing new freshwater through cloud seeding, picked up $100 million in Series B funding. The round includes investments from Noa, Upfront Ventures, DCVC, Lowercarbon Capital and Dream Ventures. 8. (tied) Numeral, $100M, tax compliance: San Francisco-based Numeral, an AI-powered sales tax compliance platform, closed on a $100 million Series C round led by Insight Partners. 8. (tied) Micro1, $100M, AI data: San Francisco-based Micro1, a provider of AI training data to major AI labs, has reportedly raised a fresh funding round of more than $100 million at a valuation of $4 billion, according to a Forbes article citing people familiar with the deal. Methodology We tracked the largest announced rounds in the Crunchbase database that were raised by U.S.-based companies for the period of Sept. 19-25, 2026. Although most announced rounds are in the database, there may be a small time lag, as some rounds are reported late in the week. Illustration: Dom Guzman Stay up to date with recent funding rounds, acquisitions, and more with the Crunchbase Daily.
document fetched 2026-09-26 02:50 · canonical https://news.crunchbase.com/venture/biggest-funding-rounds-cybersecurity-ai-health-island-cyera