loading
loading
NIH grant 1K25DK144708-01A1: Intelligent Bioelectronic Implants for the Diagnosis and Neuromodulation of Neurogenic Bladder Dysfunction
Institute: {'code': 'DK', 'abbreviation': 'NIDDK', 'name': 'National Institute of Diabetes and Digestive and Kidney Diseases', 'admin_org_id': '12500020', 'admin_funding_url': ''}. PI: Zhengwei Li. Award: $167696.
Start: 2026-08-27T00:00:00.
Project Summary
Urological dysfunction following spinal cord injury (SCI) often includes neurogenic bladder and detrusor sphincter
dyssynergia (DSD), where the external urethral sphincter (EUS) fails to relax during detrusor muscle contraction,
resulting in inefficient bladder emptying. Unfortunately, current treatments—including pharmacotherapy,
botulinum toxin injections, and electrical stimulation—offer only temporary relief and do not restore full control of
the lower urinary tract (LUT) due to the complex neuro-muscular systems involved in voiding and the lack of
advanced targeting tools. This k25 project proposes a novel approach that integrates bioelectronics with AI-
driven systems to develop intelligent, bladder-integrated bioelectronic implants for chronic monitoring and
autonomous, closed-loop neuromodulation to treat neurogenic bladder dysfunction post-SCI. Specifically, we
aim to fabricate a soft, highly expandable microelectronic system for continuous monitoring and electrical
neuromodulation, develop an intelligent wireless control system for autonomous stimulation, and assess
neurogenic bladder dysfunction in SCI animal model while investigating the effects of neuromodulation on
preventing DSD. These research objectives leverage my expertise in stretchable electronics and wireless
bioelectronics. With over ten years of experience in the field, I am well-prepared to develop intelligent
bioelectronic systems for continuous monitoring and neuromodulation, ultimately improving outcomes for
urological patients. However, while I have a strong engineering background and significant research
accomplishments, I recognize the need for formal training in urology and clinical research methodologies. My
long-term career goal is to become an independent investigator at the intersection of bioengineering and
urology, focusing on the development of innovative bioelectronic devices and urotechnologies to monitor,
diagnose, and treat urological disorders. The K25 award is crucial for bridging these gaps by providing the
mentorship, education, and clinical experience necessary for my transition to a clinical research role. My career
development plan includes formal coursework, hands-on research, clinical exposure, and professional
development activities designed to prepare me for a successful independent research career. This opportunity
will enable me to lead independent projects addressing critical urological challenges while acquiring the
biomedical expertise needed for success in this field.document fetched 2026-09-06 02:47