NIH grant: Novel Balloon Angioplasty Inflation Device (1R43HL187101-01)

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NIH grant 1R43HL187101-01: Novel Balloon Angioplasty Inflation Device
Institute: {'code': 'HL', 'abbreviation': 'NHLBI', 'name': 'National Heart Lung and Blood Institute', 'admin_org_id': '12500068', 'admin_funding_url': ''}. PI: Nick  Rydberg. Award: $329537.
Start: 2026-08-15T00:00:00.
Project Summary/Abstract
We propose the development of a novel balloon angioplasty inflation device for improving the safety and
efficacy of balloon angioplasty. Atherosclerosis is associated with coronary artery disease, ischemic stroke and
peripheral arterial disease. Percutaneous balloon angioplasty, often in conjunction with stent device
deployment, has been associated with prolonged survival, increased quality of life and extended delay of
restenosis. There exists great enthusiasm for percutaneous interventions to resolve atherosclerotic symptoms.
Balloon inflation devices on the market do not adequately consider the molecular composition of the artery nor
do they consider elasticity differences between arterial beds. The proposed project explores a novel technique
to promote improved inflation performance during balloon angioplasty, resulting in less stress on the artery wall
to achieve the resultant luminal area. A prototype device will be developed and evaluated.

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