NIH grant: Center for Aging with Serious Illness (CASI) (1P20GM161873-01)

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NIH grant 1P20GM161873-01: Center for Aging with Serious Illness (CASI)
Institute: {'code': 'GM', 'abbreviation': 'NIGMS', 'name': 'National Institute of General Medical Sciences', 'admin_org_id': '12500024', 'admin_funding_url': ''}. PI: Nathan E Goldstein. Award: $2379060.
Start: 2026-06-18T00:00:00.
This Phase I Centers of Biomedical Research Excellence (COBRE) proposal establishes the Center for Aging
with Serious Illness (CASI) at Dartmouth Health (DH). The growing number of older adults living with chronic,
serious illness represents one of the most pressing public health challenges in the United States. However,
research addressing the unique needs of this population has not kept pace with its rapid expansion. Building a
robust evidence base to improve the quality of life for this group is critical to advancing healthcare. To address
this gap, it is essential that research be designed to navigate the complexities of providing care for older adults
facing serious illness. The primary goal of this COBRE is to create the foundational infrastructure required to
develop a multidisciplinary research program focused on aging with serious illness al DH, one of the most
rural academic medical centers in the country. This program will provide expert mentorship, protected research
time, and institutional support to recruit and nurture a critical mass of early-career clinician-scientists, facilitating
their transition into independent researchers dedicated to improving care for older adults with serious illness. To
achieve this overarching goal, CASI will pursue three specific aims: (1) Establish a robust framework that
integrates research expertise and mentorship to formalize CASI and strengthen DH's research infrastructure, in
collaboration with affiliate institutions; (2) Develop a structured pathway to support early-career clinicianscientists
as Research Project Leaders (RPLs) and enhance their transition to independent investigators through
tailored, milestone-driven research plans; and, (3) Ensure the success of RPLs and Pilot Project Leaders by
providing comprehensive technical assistance through the Biostatistics, Ethics, Data Management, Research
Design, and Community Engagement (BEDRoC) Core, which will serve the broader DH research community
focused on improving care for older adults with serious illness. CASI will concentrate on building a network of
experts who will conduct clinical, behavioral, and health services research to address the challenges faced by
older adults with serious illness. Our investigators will focus on solving key issues in aging with serious illness
and use their findings to inform healthcare policy and stakeholder decision-making. The initial three RPLs will
focus on shared decision-making for surgery in older adults, palliative care for older patients with cancer, and
management of osteoarthritis in older adults with multimorbidity. The BEDRoC Core will support CASI by: (1)
Providing the three RPLs specialized expertise in statistical analysis, research ethics, and community
engagement to aid in the planning and execution of their projects, and (2) Creating an innovative learning
collaborative that provides workshops, tutorials, resources, and services to promote continuous researcher
development. COBRE funding, combined with substantial institutional investment and plans to hire additional
faculty, will lay a strong foundation for creating a self-sustaining, vibrant Center. This Center will foster
independent investigators whose work will ultimately improve the care and quality of life for older adults.

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