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NIH grant 1RF1NS143209-01A1: Sex- and age-dependent inflammation and vascular cognitive impairment after intracerebral hemorrhage
Institute: {'code': 'NS', 'abbreviation': 'NINDS', 'name': 'National Institute of Neurological Disorders and Stroke', 'admin_org_id': '12500053', 'admin_funding_url': ''}. PI: LAUREN H SANSING. Award: $1318968.
Start: 2026-09-05T00:00:00.
Project Summary
Intracerebral hemorrhage (ICH) remains a disease with high morbidity and mortality and without effective
treatment. ICH survivors have an increased risk of cognitive decline and mood disorders, forms of vascular
contributions to cognitive impairment and dementia (VCID). However, little is known about the
pathophysiology of cognitive decline after ICH, and particularly about the role of aging and sex differences in
risk of poor cognitive outcomes.
The proposed studies will examine the interplay between sex and aging in iron-induced programmed cell death
(ferroptosis), Type 1 IFN responses in chronic neuroinflammation, and cognitive decline in experimental ICH.
Based on preliminary data, we hypothesize that aged females have heightened chronic Type 1 interferon
responses while aged male mice will have more ongoing ferroptosis. We will comprehensively define the
inflammatory responses over time in young and aged, male and female mice and determine the contribution of
ferroptosis to cognitive decline and chronic inflammation. We will test candidate causal pathways and
pharmacological inhibitors to improve outcomes after ICH and advance our understanding of sex and age
vulnerabilities to VCID after ICH.document fetched 2026-09-13 02:45