NIH grant: Trauma-Informed Smoking Cessation for Women (1K08CA300872-01A1)

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NIH grant 1K08CA300872-01A1: Trauma-Informed Smoking Cessation for Women
Institute: {'code': 'CA', 'abbreviation': 'NCI', 'name': 'National Cancer Institute', 'admin_org_id': '12500008', 'admin_funding_url': ''}. PI: Anita  Hargrave. Award: $306304.
Start: 2026-07-02T00:00:00.
ABSTRACT
Cigarette smoking is the leading preventable cause of premature cancer-related mortality in the US. Quitting
smoking lowers cancer risk, improves mental health, and can increase life expectancy by 10 years. Women are
less successful in their attempts to quit smoking and their rates of quitting are lower than that of men. Women
experience greater smoking-related disease and increased risk of mortality from smoking. Women face distinct
challenges which can impede smoking cessation. One particularly important factor is psychological trauma.
Women have a greater prevalence of trauma exposure and are three times more likely to experience post-
traumatic stress disorder compared to men. Trauma is a significant risk factor for smoking initiation and is
associated with lower quit rates and increased cancer risk in women. However, no national studies have
examined the impact of trauma on difficulty with tobacco cessation in women. Further, though the use of trauma-
informed approaches has improved treatment engagement and outcomes for patients with alcohol and other
substance use, studies have not evaluated trauma-informed approaches to tobacco cessation in women. The
proposed training and research plan for this K08 application will enable Dr. Anita Hargrave to obtain the
necessary skills to achieve her career goal of becoming an independent NIH-funded clinician-investigator
leveraging expertise in advanced statistical analyses, implementation science, and clinical trials to improve
tobacco cessation and women’s cancer prevention using trauma-informed approaches. With a highly
experienced mentorship team and a thorough training plan, Dr. Hargrave will build on her prior experience in
trauma and cancer-related research to obtain mastery in using nationally representative survey data, applying
implementation science behavior change theory, and conducting a pilot randomized controlled trial. This training
will complement and facilitate the completion of her research aims: (1) assess challenges to successful tobacco
cessation among women with and without trauma histories using a national survey; (2) conduct a formative
evaluation using an implementation framework to adapt an evidence-based tobacco cessation intervention by
incorporating trauma-informed approaches; (3) determine the feasibility and acceptability of the novel trauma-
informed tobacco cessation intervention in a 12-month pilot randomized controlled trial (RCT). The proposed
research will inform the development of an R01 application to evaluate the trauma-informed tobacco cessation
intervention in a full-scale RCT, with the goal of improving tobacco cessation and cancer prevention for women
with histories of trauma.

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