NIH grant: Mechanisms and Barriers in Nanomedicine (1R13EB040107-01)

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NIH grant 1R13EB040107-01: Mechanisms and Barriers in Nanomedicine
Institute: {'code': 'EB', 'abbreviation': 'NIBIB', 'name': 'National Institute of Biomedical Imaging and Bioengineering', 'admin_org_id': '12500035', 'admin_funding_url': ''}. PI: Rajarshi  Chattaraj. Award: $10000.
Start: 2026-07-17T00:00:00.
Abstract.
Nanomedicine research has shown remarkable progress in recent years in the detection and therapy of a range
of human diseases, including cancer, and inflammatory, cardiovascular, and neurodegenerative diseases.
However, a better understanding of how nanomedicine interacts with biological and immunological barriers is
still needed to further improve the efficacy of nanomedicine and facilitate its clinical translation. To discuss these
challenges and opportunities, we propose organizing a conference-workshop, “Mechanisms and Barriers in
Nanomedicine,” that will bring together expert nanomedicine scientists and trainees. The conference will be
modeled after our previous conferences in 2016 and 2023 and provide an informal venue for open discussion
on barriers in nanomedicine. The third iteration of this meeting will focus on protein-material interactions and
their implications on how nanomedicines interact with biological barriers. The meeting will also work towards
paradigm-shifting approaches for leveraging protein-material interactions to overcome biological barriers. The
main innovation of the conference-workshop is the provision of an open forum for discussing problems in
nanomedicine and the focus on its biological and translational aspects. The program will be focused on the
following aspects: a) Formation, composition, and applications of protein corona, b) Impact of protein corona on
the interactions of nanomaterials with biological barriers, c) emerging technologies to study protein corona, d)
leveraging endogenous proteins for improved drug delivery, and e) challenges to translation of nanomedicine.
Leading experts will discuss the roles of the protein corona, immune and endothelial cells, and the tumor
microenvironment in the functionality of nanomedicines. We aim to achieve the following goals: a) to provide an
educational, yet critical, forum into impact of nano-bio interactions, with focus on proteins, on the efficacy of
nanomedicines; b) to present an update of the field on understanding these challenges and potential paradigm
shift strategies to mitigating these problems; c) by conducting open, unrestricted, non-proprietary discussion
among senior faculty, young investigators and graduate students, we hope to trigger new ideas and concepts
that will move the field forward. Overall, this meeting will be a place where young scientists and students can
learn from experienced scientists in an inclusive and informal environment. The R13 grant will be used to help
with conference attendance for students and postdocs.

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